CBMA

The main focus of my current work is studying human hair biology responsible for hair shape and texture as well as hair follicle aging, commonly perceived as hair graying.

Finding the genetic basis for a particular hair shape will allow to develop hair cosmetics able to modulate the levels of target genes and, ultimately, able to shape hair according to our will.

Understanding how microRNAs are involved in hair graying is also one of our goals; though the common sense dictates that aging is inevitable and irreversible, hair repigmentation has been reported as a side-effect on the treatment of many diseases, raising the possibility of finding new solutions to recover the loss of hair melanin. Our aim is to reverse hair graying by modulating particular microRNAs levels.

My side work projects regard biotechnology and nanotechnology applied to textile, cosmetic and health care industries, mainly in the interface with animal cell biology and microbiology for the extensive biological caracterization of a particular material.

Matamá T, Gomes AC, Cavaco-Paulo A (2015) Hair Coloration by Gene Regulation: Fact or Fiction? Trends in Biotechnology 33 (12): 707–711

Matamá T, Araújo R, Preto A, Cavaco-Paulo A, Gomes AC (2013). In vitro induction of melanin synthesis and extrusion by tamoxifen. International Journal of Cosmetic Science 35: 368–374.

Ribeiro A, Matamá T, Cruz C, Gomes AC, Cavaco-Paulo A (2013). Potential of human gammaD-crystallin for hair damage repair: insights into the mechanical properties and biocompatibility. International Journal of Cosmetic Science 35: 458–466.

Silva C‡, Matamá T‡, Azoia NG, Mansilha C, Casal M, Cavaco-Paulo A (2014) Odorant binding proteins: a biotechnological tool for odour control. Applied Microbiology and Biotechnology 98(8):3629-38.

Lopes C, Fonseca P, Matamá T, Gomes A, Louro C, Paiva S, Vaz F (2014) Protective Ag:TiO2 thin films for pressure sensors in orthopedic prosthesis: the importance of composition, structural and morphological features on the biological response of the coatings. Journal of Materials Science: Materials in Medicine. DOI 10.1007/s10856-014-5251-z

‡ both 1st authors equally contributed to the work

NOVO  (FP7-HEALTH-2011.2.3.1-5), European project funded under 7th Framework Programme - Novel approaches for prevention and degeneration of pathogenic bacteria biofilms formed on medical devices e.g. catheters

BioSYNTEX (G5RD-CT-2001-00560), from the European Union 5th Framework Program - GROWTH
(This project intended the modification of synthetic fibers in order to obtain the desired end-product properties using eco-efficient finishing wet-processes that do not require high amounts of energy and chemicals, in contrast with the tradicional industrial methods).

Lidwine (NMP2-CT-2006-026741), European project funded under 6th Framework Programme - Multifunctional Medical Textiles for wound (e.g. Decubitus) prevention and improved wound healing

Biorenew (NMP2-CT-2006-026456), European project funded under 6th Framework Programme - White Biotechnology for added value products from renewable plant polymers: Design of tailor-made biocatalysts and new industrial bioprocesses

2015

Zhao X, Matama T, Ribeiro A, Silva C, Wu J, Fu J, Cavaco-Paulo A (2015) Cutinase promotes dry esterification of cotton cellulose. Biotechnology Progress (doi: 10.1002/btpr.2194)

Ferreira H, Silva R, Matamá T, Silva C, Gomes A, Cavaco-Paulo A (2015) A biologically active wound dressingdelivery material with dried-rehydrated vesicles containing the anti-inflammatory diclofenac for potential wound healing. Journal of Liposome Research 4: 1-7 (doi: 10.3109/08982104.2015.1108333)

Matamá T, Gomes AC, Cavaco-Paulo A (2015) Hair Coloration by Gene Regulation: Fact or Fiction? Trends in Biotechnology 33 (12): 707–711 (doi: 10.1016/j.tibtech.2015.10.001)

Martins M, Azoia NG, Carvalho AC, Silva C, Matamá T, Gomes AC, Cavaco-Paulo A (2015) Assessment of a Protease Inhibitor Peptide for Anti-Ageing. Protein Peptide Letters 22 (11): 1041-1049. (doi: 10.2174/0929866522666150907111351)

Fernandes B, Silva R, Ribeiro A, Matamá T, Botelho C, Gomes AC, Cavaco-Paulo A (2015) Improved Poly (D, L-lactide) nanoparticles-based formulation for hair follicle targeting. International Journal of Cosmetic Sciences 37(3): 282-290 (doi: 10.1111/ics.12197)

Gonçalves I, Abreu A, Matamá T, Ribeiro A, Gomes A, Silva CM, Cavaco-Paulo A (2015) Enzymatic synthesis of poly(catechin)-antibiotic conjugates: an antimicrobial approach for indwelling catheters. Applied Microbiology and Biotechnology 99 (2): 637-651. (doi: 10.1007/s00253-014-6128-2)

2014

Martins M, Azoia NG, Shimanovich U, Matamá T, Gomes AC, Silva C, Cavaco-Paulo A (2014) Design of Novel BSA/Hyaluronic Acid Nanodispersions for Transdermal Pharma Purposes. Molecular Pharmaceutics 11(5):1479-88. (doi: 10.1021/mp400657)

Silva C‡, Matamá T‡, Azoia NG, Mansilha C, Casal M, Cavaco-Paulo A (2014) Odorant binding
proteins: a biotechnological tool for odour control. Applied Microbiology and Biotechnology 98(8):3629-38.
(DOI 10.1007/s00253-013-5243-9)

Lopes C, Fonseca P, Matamá T, Gomes A, Louro C, Paiva S, Vaz F (2014) Protective Ag:TiO2 thin films for pressure sensors in orthopedic prosthesis: the importance of composition, structural and morphological features on the biological response of the coatings. Journal of Materials Science: Materials in Medicine. 25(9):2069-81. (doi: 10.1007/s10856-014-5251-z)

Gonçalves I, Matamá T, Cavaco-Paulo A, Silva CM (2014). Laccase coating of catheters with
poly(catechin) for biofilm reduction. Biocatalysis and Biotransformation 32(1): 2-12. (doi:10.3109/10242422.2013.828711)

2013

Ribeiro A, Matamá T, Cruz C, Gomes AC, Cavaco-Paulo A (2013). Potential of human gammaD-crystallin for hair damage repair: insights into the mechanical properties and biocompatibility. International Journal of Cosmetic Science 35: 458–466.

Gomes DS, Matamá T, Cavaco-Paulo A, Campos-Takaki GM, Salgueiro AA (2013). Production of heterologous cutinases by E. coli and improved enzyme formulation for application on plastic degradation. Electronic Journal of Biotechnology, vol. 16, no. 5. http://dx.doi.org/10.2225/vol16-issue5-fulltext-12

Stepan AM, Anasontzisa GE, Matama T, Cavaco-Paulo A, Olsson L, Gatenholm P (2013) Lipases efficiently stearate and cutinases acetylate the surface ofarabinoxylan films. Journal of Biotechnology 167: 16–23.

Matamá T, Araújo R, Preto A, Cavaco-Paulo A, Gomes AC (2013). In vitro induction of melanin synthesis and extrusion by tamoxifen. International Journal of Cosmetic Science 35: 368–374.

Ferreira H, Matamá T, Silva R, Silva C, Gomes AC, Cavaco-Paulo A (2013) Functionalization of gauzes with liposomes entrapping an anti-inflammatory drug: A strategy to improve wound healing. Reactive & Functional Polymers 73: 1328–1334.

Antunes E, Azóia NG, Matamá T, Gomes AC, Cavaco-Paulo A (2013) The activity of LE10 peptide on biological membranes using molecular dynamics, in vitro and in vivo studies. Colloids and Surfaces B: Biointerfaces 106: 240– 247.

Kim S‡, Fernandes M‡, Matamá T, Loureiro A, Gomes A, Cavaco-Paulo A (2013) Chitosan-lignosulfonates sono-chemically prepared nanoparticles: characterisation and potential applications. Colloids and Surfaces B: Biointerfaces 103: 1– 8.

Matamá T, Casal M, Cavaco-Paulo A (2013) Direct enzymatic esterification of cotton and Avicel with wild-type and engineered cutinases. Cellulose 20: 409–416.

2012

Silva R, Ferreira H, Matamá T, Gomes A, Cavaco-Paulo A (2012) Wound healing evaluation of encapsulated active agents into protein microspheres over cellulosic gauzes. Biotechnology Journal 7: 1376–1385.

Silva C, Azoia NG, Martins M, Matamá T, Wu J, Cavaco-Paulo A (2012) Molecular recognition of esterase plays a major role on the removal of fatty soils during detergency. Journal of Biotechnology 161: 228– 234.

2011

Silva C, Da S, Silva N, Matamá T, Araújo R, Martins M, Chen S, Chen J, Wu J, Casal M, Cavaco-Paulo A (2011) Engineered Thermobifida fusca cutinase with increased activity on polyester substrates. Biotechnology Journal 6: 1230–1239.

Silva C, Matamá T, Kim SY, Padrão J, Prasetyo EN, Kudanga T, Nyanhongo GS, Guebitz GM, Casal M, Cavaco-Paulo A (2011) Antimicrobial and antioxidant linen via laccase-assisted grafting. Reactive & Functional Polymers 71: 713-720.

2003 - 2010

Matamá T, Araújo R, Gübitz GM, Casal M, Cavaco-Paulo A (2010) Functionalization of cellulose acetate fibers with engineered cutinases. Biotechnology Progress, 26: 636–643.

Matamá T‡, Carneiro F‡, Caparrós C, Gübitz GM, Cavaco-Paulo A (2007) Using a nitrilase for the surface modification of acrylic fibres. Biotechnology Journal 2: 353-260.

Fischer-Colbrie G, Matama T, Heumann S, Martinkova L, Paulo AC, Guebitz G (2007) Surface hydrolysis of polyacrylonitrile with nitrile hydrolysing enzymes from Micrococcus luteus BST20. Journal of Biotechnology 129: 62-68.

Matamá T, Vaz F, Gübitz GM, Cavaco-Paulo A (2006) The effect of additives and mechanical agitation in surface modification of acrylic fibres by cutinase and esterase. Biotechnology Journal 1: 842–849.

Silva C, Matamá T, Guebitz GM, Cavaco-Paulo A (2005) Influence of the organic solvents on cutinase stability and accessibility to polyamide fibres. Journal of Polymer Science Part A: Polymer Chemistry 43: 2749-2753.

Santos M, Costa MC, Rio ME, Sá MJ, Monteiro M, Valença A, Sá A, Dinis J, Figueiredo J, Almeida LB, Valongueiro A, Coelho I, Matama MT, Pinto-Basto J, Sequeiros J, Maciel P (2004) Genotypes at the APOE and SCA2 loci do not predict the course of multiple sclerosis in patients of Portuguese origin. Multiple Sclerosis 10: 153-157.

Martins S, Matama T, Guimarães L, Vale J, Guimarães J, Ramos L, Coutinho P, Sequeiros J, Silveira I (2003) Portuguese families with dentatorubropallidoluysian atrophy (DRPLA) share a common haplotype of Asian origin. European Journal of Human Genetics 11: 808-811.

‡ both 1st authors that equally contributed to the work

Matamá T and Cavaco-Paulo A (2014) Cellulose biomodification with cutinase fusion proteins. In: Cellulose and Other Naturally Occurring Polymers, Fontana JD, Tiboni M and Grzybowski A (editors), Research Signpost, India, Chapter 3, pp. 21-31. ISBN: 978-81-308-0543-6

Silva C, Matamá T and Cavaco-Paulo A (2010) Biotransformation Of Synthetic Fibers. In: Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, Flickinger M C (editor), Germany, Wiley-VCH. ISBN: 978-0-471-79930-6

Matamá T and Cavaco-Paulo A (2010) Enzymatic modification of polyacrylonitrile and cellulose acetate fibres for textile and other applications. In: Advances in textile biotechnology, Nierstrasz V and Cavaco-Paulo A (editors), Woodhead Publishing Limited, United Kingdom, Part II, Chapter 5, pp. 98-131. ISBN: 9781845696252

Matamá T (2009), Surface functionalization of acrylic and cellulose acetate fibres, Germany, VDM Verlag Dr. Müller. ISBN: 978-3-639-20376-9

Cavaco-Paulo A, Carneiro AFC, Silva CMP, Araújo RIL, Gübitz G, Casal MPPA, Matamá MTGM (2005).
Method for modification of polyacrylonitrile fibres containing vinyl acetate as a comonomer and polyanyde fibres, using cutinase. Internacional Patent WO 2005/040487 A1.

Matamá T (2007). The 4th International Conference on Textile Biotechnology – Meeting report. Biotechnol J 2: 304–305.

Oral communications

Matamá T, Araújo R, Preto A, Gomes A, Cavaco-Paulo A. Tamoxifen speeds up melanin extrusion in normal human melanocytes. 16th EHRS Annual Meeting, Barcelona June 21st-23rd, 2012.

Araújo R, Matamá T, Preto A, Cavaco-Paulo A, Gomes A. Discovering messenger RNA and micro RNA expression patterns in normal, greying hair. 16th EHRS Annual Meeting, Barcelona June 21st-23rd, 2012.

Matamá T, Araújo R, Gübitz GM, Casal M, Cavaco-Paulo A. Superficial hydrolysis of cellulose acetates with cutinase and cutinase fused to carbohydrate-binding modules. COST Action 868: Biotechnical functionalization of renewable polymeric materials, Varna, Bulgaria, September 18-19, 2008.

Matamá T, Araújo R, Casal M, Cavaco-Paulo A. Enzymatic modification of cellulose acetate with fusion proteins. The 235th ACS National Meeting & Exposition, New Orleans, LA, April 6-10, 2008.

Silva NM, Matamá T, Casal M, Cavaco-Paulo A. Cellulose-binding modules for medical applications. The 235th ACS National Meeting & Exposition, New Orleans, LA, April 6-10, 2008.

Matamá T, Caparrós C, Gübitz GM, Cavaco-Paulo A. Enzymatic modification of acrylic fibres. The 4th International Conference on Textile Biotechnology, Seoul, June 4-7, 2006.

Matama T, Silva C, O'Neill A, Casal M, Soares C, Guebitz GM, Cavaco-Paulo A. Improving synthetic fibres with enzymes. The 3th International Conference on Textile Biotechnology, Graz, June 13-16, 2004.

Matama T, Silva C, O'Neill A, Araújo R, Guebitz GM, Cavaco-Paulo A. Monitoring biotransformations in synthetic fibres. The 227th ACS National Meeting, Anaheim, CA, March 28-April 1, 2004.

Silva C, Matamá, O’Neill A, Carneiro F, Cavaco-Paulo A. Monitoring hydrolytic transformations in synthetic fibres. Cost Meeting, Belfast, January 2004.

Miranda C, Cerqueira J, Matamá T, Mendonça P, Barros J, Nunes L, Silveira I, Coutinho P, Barbot C, Sequeiros J. Cinco Anos de Diagnóstico Molecular da Ataxia de Friedreich em Portugal. Fórum de Neurologia, Luso, May 20-23, 2004.

Costa MC, Magalhães M, Matamá MT, Ferreirinha F, Cerqueira J, Sequeiros J, Maciel P. Estudo genético de doentes portugueses com fenótipo Huntington-like. IV Encontro Luso-brasileiro de Neurologia, Lisboa, November 20-23, 2003.

Alonso I, Coelho J, Mendonça P, Matamá T, Jardim L, Costa C, Januário C, Pavão I, Tuna A, Barros J, Coutinho P, Sequeiros J, Silveira I. Caracterização molecular de gene CACNA1A em 6 famílias com Enxaqueca Hemiplégica ou Ataxia Episódica do Tipo 2. XXXVII Conferências de Genética, Porto, February 1-2, 2001.

Anabela Ferreira Gonçalves, Master thesis in Molecular Genetics, 2015-2016. Development of skin equivalents and their characterization for in vitro testing. (Co-supervision)

Diana Guimarães, Master thesis in Molecular Genetics, 2013-2014. Understanding the effect of certain microRNAs on the regulation of melanin production. (Co-supervision)

Cristiana Costa, Master thesis in Molecular Genetics, 2013-2014. Study of the in situ expression patterns of genes in the hair follicle potentially important for hair morphology. (Co-supervision)