CBMA
Centro de Biologia Molecular e Ambiental
Centre of Molecular and Environmental Biology
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| André Costa | |
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| Post-Doc Researcher | |
| Innovation for Life - Functional Genomics and Nanobiotechnology for Sustainable Living | |
| Functionalization, design and bioproduction of Protein-Based Polymers | |
| Raul Machado | |
| Departamento de Biologia,
Universidade do Minho - Campus de Gualtar, - 4710-057, Braga - Portugal |
Current Research & Key Publications
AREA OF CURRENT SCIENTIFIC ACTIVITY: - Molecular biology/biotechnology TECHNICAL SKILLS: - Molecular biology procedures
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Research Projects
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Publications
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- da Costa A., Machado R., Ribeiro A., Gomes A., Rodríguez-Cabello J.C., Casal M. “Development of an ex vivo assay for the characterization of a new elastin-like polymer with antimicrobial properties”. 2013. Journal of Tissue Engineering and Regenerative Medicine, 7, Suplement s1, Page 11 (TS11) - Machado R., da Costa A., Sencadas V., Gomes A., Lanceros-Mendez S., Rodríguez-Cabello J.C., Casal M. “Electrospun recombinant Protein-Based Polymers fibre matrices for skin regeneration”. 2013. Journal of Tissue Engineering and Regenerative Medicine, 7, Suplement s1, Page 12 (TS14) - Pereira A.M., Bernardo T.C., da Costa A., Collins T., Machado R., Leonor I.B., Casal M., Reis R.L. “Development of new chimeric proteins for tissue engineering”. 2013. Journal of Tissue Engineering and Regenerative Medicine, 7, Suplement s1, Page 11 (TS11). - Pereira A.M., Bernardo T.C., da Costa A., Collins T., Machado R., Leonor I.B., Casal M., Reis R.L. “Development of new chimeric proteins for tissue engineering”. 2013. Journal of Tissue Engineering and Regenerative Medicine, 7, Suplement s1, Page 46 (POL07). - Collins T., Barroca M., Branca F., Azevedo-Silva J., da Costa A., Machado R., Casal M. “Optimising a cell factory system for the bioproduction of silk-elastin-like polymers”. 2013. 1st Internacional Conference on Natural Fibres (ICNF2013): Sustainable Materials for Advanced Applications, page 127. Raul Fangueiro (Editor), Guimarães, Portugal. ISBN: 978-989-20-3872-8 - Machado R., da Costa A., Sencadas V., Azevedo-Silva J., Collins T., Arias F.J., Lanceros-Mendez S., Rodríguez-Cabello J.C., Casal M. “Synthesis and processing of recombinant silk and elastin copolymers”. 2013. 1st Internacional Conference on Natural Fibres (ICNF2013): Sustainable Materials for Advanced Applications, page 153. Raul Fangueiro (Editor), Guimarães, Portugal. ISBN: 978-989-20-3872-8 - Campos A.R., Oliveira B., Machado R., Collins T., Azevedo-Silva J., da Costa A., Immonen K., Wikström L., Casal M. “Novel nanocellulose reinforced recombinant protein based polymer composites”. 2013. 1st Internacional Conference on Natural Fibres (ICNF2013): Sustainable Materials for Advanced Applications, page 333. Raul Fangueiro (Editor), Guimarães, Portugal. ISBN: 978-989-20-3872-8 |
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PODIUM COMMUNICATIONS BY INVITATION: - da Costa A. “The importance of polymers in the antimicrobial world” Advanced Course on "Biopolymers based on renewable resources: from synthesis to applications (3rd Edition)" 11-22 April 2016, Universidade do Minho, Braga, Portugal - da Costa A. “Functionalization of Protein-based Polymers for advanced biomaterials” DBio Seminars. 9th December 2015, Universidade do Minho, Braga, Portugal - da Costa A. and Machado R. “Methodologies for the assessment of biopolymer's antimicrobial activity” Advanced Course on "Biopolymers based on renewable resources: from synthesis to applications (2nd Edition)" 7-17 April 2015, Universidade do Minho, Braga, Portugal - da Costa A. “Development of a recombinant protein-based polymer exhibiting antimicrobial properties” DBio Seminars. 15th January 2014, Universidade do Minho, Braga, Portugal - da Costa A. “Functionalization of Elastin-Like Polymers (ELPs) as antimicrobial materials” DBio Seminars. 31st October 2012, Universidade do Minho, Braga, Portugal
PODIUM COMMUNICATIONS:
- da Costa A., Machado R., Rodríguez-Cabello J.C., Gomes A.C., Casal M. “Creation of antimicrobial biopolymers by the use of recombinant DNA technology” XL Portuguese Genetics Conference, June 3 2016, Coimbra, Portugal. - Pereira A.M., Machado R., Bernardo T., da Costa A., Ribeiro A., Collins T., Gomes A.C., Leonor I., Kaplan D.L., Reis R.L., Casal M. “Genetically engineered silk-based composite biomaterials functionalized with fibronectin type-II that promote cell adhesion”. XL Portuguese Genetics Conference, June 3 2016, Coimbra, Portugal. - Pereira A.M., Machado R., Bernardo T., da Costa A., Ribeiro A., Collins T., Gomes A.C., Leonor I., Kaplan D.L., Reis R.L., Casal M. “Advanced silk-based genetic polymers with improved cell adhesion properties”. MicroBiotec’15, December 10 – 12, 2015, Évora, Portugal. - da Costa A., Machado R., Ribeiro A., Collins T., Thiagarajan V., Neves-Petersen M. T., Rodríguez-Cabello J.C., Gomes A.C., Casal M. “Synthetic Protein Biotechnology approaches for the creation of antimicrobial biopolymers” XXXIX Portuguese Genetics Conference, May 25-27 2015, Braga, Portugal. - da Costa A., Machado R., Sencadas V., Lanceros-Méndez S., Gomes A.C., Rodriguez-Cabello J.C., Casal M. “Electrospun fibres of an elastin-like recombinamer functionalized with an antimicrobial domain” ICNF2015, April 27-29 2015, S. Miguel, Açores, Portugal - Machado R., Silva A.M., da Costa A., Gomes A.C., Rodríguez-Cabello J.C., Lanceros-Méndez S., Sencadas V., Casal M. “Antimicrobial electrospun membranes of SELP/Ag composites” ICNF2015, April 27-29 2015, S. Miguel, Açores, Portugal - Campos A.R., Oliveira B., Machado R., Collins T., Azevedo-Silva J., da Costa A., Immonen K., Wikström L., Casal M. “Nanocellulose composites using a recombinant protein based polymer as a matrix” ICNF2015, April 27-29 2015, S. Miguel, Açores, Portugal - da Costa A., Machado R., Ribeiro A., Collins T., Viruthachalam T., Neves-Petersen M.T., Rodríguez-Cabello J.C., Gomes A.C., Casal M. “A new highly antimicrobial bio-inspired protein-based polymer designed for medical devices” ICAR2014, October 1-3 2014, Madrid, Spain - da Costa A., Machado R., Ribeiro A., Gomes A., Rodríguez-Cabello J.C., Casal M. “Antibacterial and antifungal activity of a new solvent-cast film based on a functionalized elastin-like polymer” MICROBIOTEC ’13, December 6-8 2013, Aveiro, Portugal - Machado R., da Costa A., Sencadas V., Gomes A., Lanceros-Mendez S., Rodríguez-Cabello J.C., Casal M. “Electrospun recombinant Protein-Based Polymers fibre matrices for skin regeneration” Term Stem 2013, October 10-12 2013, Porto, Portugal - da Costa A., Machado R., Ribeiro A., Gomes A., Rodríguez-Cabello J.C., Casal M. “A synthetic biology approach for the development of recombinant protein-based polymers exhibiting antimicrobial properties” European Symposium on Biopolymers (ESBP 2013), October 7- 9 2013, Lisboa, Portugal. - Collins T., Barroca M., Branca F., Azevedo-Silva J., da Costa A., Machado R., Casal M. “Optimising a cell factory system for the bioproduction of silk-elastin-like polymers” 1st International Conference on Natural Fibres (ICNF2013), June 9-11 2013, Guimarães, Portugal. - Machado R., da Costa A., Sencadas V., Azevedo-Silva J., Collins T., Arias F.J., Lanceros-Mendez S., Rodríguez-Cabello J.C., Casal M. “Synthesis and processing of recombinant silk and elastin copolymers” 1st International Conference on Natural Fibres (ICNF2013), June 9-11 2013, Guimarães, Portugal. - da Costa A., Machado R., Casal M. “Solvent-cast films of an elastin-like polymer fused to an antimicrobial peptide, ABP-CM4, exhibits high antibacterial activity against P. aeruginosa”, Microbiotec’11, December 2011, Braga, Portugal POSTER COMMUNICATIONS: - Gomes, D., da Costa A., Pereira A.M., Casal M., Machado R., “Formulation of biocomposites based on recombinant proteins and plant essential oils for the development of active wound dressings”, XL Portuguese Genetics Conference, June 3 2016, Coimbra, Portugal - Machado R., Silva A.M., da Costa A., Gomes A.C., Sencadas V., Casal M., “Antimicrobial activity of genetically engineered silk-elastin-like composite materials”, XL Portuguese Genetics Conference, June 3 2016, Coimbra, Portugal. - da Costa A., Machado R., Sencadas V., Lanceros-Méndez S., Gomes A.C., Rodriguez-Cabello J.C., Casal M. “Electrospun fibres of an elastin-like recombinamer functionalized with an antimicrobial domain”, Microbiotec’15, December 10 – 12, 2015, Évora, Portugal - Machado R., Silva A.M., da Costa A., Gomes A.C., Rodríguez-Cabello J.C., Lanceros-Méndez S., Sencadas V., Casal M. “Fabrication of antimicrobial composite materials comprising a genetically engineered copolymer”. MicroBiotec’15, December 10 – 12, 2015, Évora, Portugal - Pereira A.M., Machado R., Bernardo T.C., da Costa A., Ribeiro A., Collins T., Gomes A.C., Leonor I., Kaplan D., Reis R.L., Casal M. “Silk-based polymers functionalized with fibronectin type-II for improved cell adhesion” III symposium of the PDBMA, November 26, 2015, Braga, Portugal - Pereira A.M., Viana J.F.C., da Costa A., Machado R., Ferreira A.C.R., Casal M., Franco O.L., Dias S.C. “Heterologous expression of antimicrobial peptide synoeca-mp fused to recombinant protein-based polymer as platform for biomaterials” 23rd International Congress of the International Union for Biochemistry and Molecular Biology (IUBMB) and 44th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology, 24 – 28 August 2015, Foz do Iguaçu, PR, Brazil. - Machado R., Silva A.M., da Costa A., Gomes A.C., Rodríguez-Cabello J.C., Lanceros-Mendez S., Sencadas V., Casal M. “Antibacterial activity of genetically engineered silk-elastin-like films and fibres containing silver nanoparticles” XXXIX Jornadas Portuguesas de Genética, May 25-27, 2015, Braga, Portugal - Pereira A.M., Machado R., Bernardo T., da Costa A., Ribeiro A., Collins T., Gomes A.C., Leonor I., Kaplan D.L., Reis R.L., Casal M. “Silk-based polymers functionalized with fibronectin type-II for improved cell adhesion”XXXIX Jornadas Portuguesas de Genética, May 25-27, 2015, Braga, Portugal - Pereira A.M., Machado R., da Costa A., Ribeiro A., Collins T., Gomes A.C., Leonor I.B., Reis R.L., Casal M. “Functionalized silk-based polymers as advanced biomaterials” II Symposium of the PDBMA, November 27, 2014, Braga, Portugal - Silva A.M., da Costa A., Chitas R., Collins T., Gomes A., Rodríguez-Cabello J.C., Lanceros-Méndez S., Sencadas V., Casal M, Machado R. “Fabrication of SELP/Ag nanocomposite materials with antimicrobial properties by electrospinning and solvent casting" International Conference on Antimicrobial Research (ICAR 2014), October 1-3, 2014, Madrid, Spain - Machado R., da Costa A., Sencadas V., Gomes A., Lanceros-Mendez S., Rodríguez-Cabello J.C., Casal M. “Electrospun silk-elastin-like fiber mats for tissue engineering applications” Microbiotec’13, December 6-8, 2013, Aveiro, Portugal - Machado R., da Costa A., Sencadas V., Gomes A., Lanceros-Mendez S., Rodríguez-Cabello J.C., Casal“Electrospun silk-elastin-like fiber mats with potential application for tissue engineering” Electrospinning, Principles, Possibilities and Practice 2013, December 5-6, 2013, Institute of Physics, London, UK - da Costa A., Machado R., Ribeiro A., Gomes, A., Rodriguez-Cabello J.C., Casal M. “Antibacterial and antifungal activity of a new solvent-cast film based on a functionalized elastin-like polymer” I Symposium of the PDBMA, November 28, 2013, Braga, Portugal - Pereira A.M., Bernardo T.C., da Costa A., Collins T., Machado R., Leonor I.B., Casal M., Reis R.L. “Development of New Chimeric Proteins for Tissue Engineering” I Symposium of the PDBMA, November 28, 2013, Braga, Portugal - da Costa A., Machado R., Ribeiro A., Gomes A., Rodríguez-Cabello J.C., Casal M. “Development of functionalized recombinant protein-based polymers exhibiting antimicrobial properties” Materials Today Virtual Conference: Biomaterials, November 19-21, 2013, online conference (http://www.materialstoday.com/virtualconference/materials-today-virtual-conference-biomaterials-2013) - Machado R., da Costa A., Sencadas V., Gomes A., Lanceros-Mendez S., Rodríguez-Cabello J.C., Casal M. “Fabrication of recombinant silk-elastin-like fiber mats for tissue engineering applications” Materials Today Virtual Conference: Biomaterials, November 19-21, 2013, online conference (http://www.materialstoday.com/virtualconference/materials-today-virtual-conference-biomaterials-2013) - da Costa A., Machado R., Ribeiro A., Gomes A., Rodríguez-Cabello J.C., Casal M. “Development of an ex vivo assay for the characterization of a new elastin-like polymer with antimicrobial properties” Term Stem 2013, October 10-12, 2013, Porto, Portugal - Pereira A.M., Bernardo T.C., da Costa A., Collins T., Machado R., Leonor I.B., Casal M., Reis R.L. “Development of new chimeric proteins for tissue engineering” Term Stem 2013, October 10-12, 2013, Porto, Portugal - Pereira A.M., Bernardo T.C., da Costa A., Collins T., Machado R., Leonor I.B., Casa M. l, Reis R.L. “Development of new chimeric proteins for tissue engineering” 1st Polaris Workshop, October 7-9, 2013, Porto, Portugal. - Machado R., da Costa A., Sencadas V., Gomes A., Lanceros-Mendez S., Rodríguez-Cabello J.C., Casal M. “Electrospun silk-elastin-like fibre matrices for tissue engineering applications” European Symposium on Biopolymers (ESBP 2013), October 7-9 2013, Lisboa, Portugal. - Pereira A.M., Bernardo T.C., da Costa A., Collins T., Machado R., Leonor I.B., Casal M., Reis R.L. “Development of new chimeric proteins for tissue engineering” 3rd ICVS/3B's Meeting, June 28, 2013, Braga, Portugal. - Collins T., Azevedo-Silva J., da Costa A., Machado R., Casal M. “Key stress factors and parameters for bath production optimisation of silk-elastin-like proteins in E. coli” Microbiotec’11, Braga, December 2011 - da Costa A., Azevedo-Silva J., Machado R., Rodriguez-Cabello J. C., Casal M.”Designing a cost-effective protein purification protocol using Elastin Like Polymer (VPAVG)200 fusion tag” XXXVI Jornadas Portuguesas de Genética, Coimbra, May 2011 - Azevedo-Silva J., da Costa A., Machado R., Rodríguez-Cabello J.C. and Casal M. “Use of Elastin Like Polymer (VPAVG)200 fusion tags for recombinant protein production and purification” XVII Congresso Nacional de Bioquímica, Porto, December 2010 - da Costa A., Machado R., Matamá T., Rodriguez-Cabello J.C., Cavaco-Paulo A., Casal M. “Production and purification of recombinant antimicrobial peptides by exploiting the termoresponsiveness of the elastin-like polymer based on the VPAVG sequence”, XXXV Jornadas Portuguesas de Genética, Braga, June 2010
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