CBMA

26. Talaia G, Gournas C; Saliba E; Barata-Antunes C; Casal M; André B; Diallinas G; Paiva S. (2017). The ?-arrestin Bul1p mediates the endocytic turnover of Jen1p lactate transporter in response to alkalinization and distinct physiological signals. Journal of Molecular Biology. 429(23): 3678-3695.

25. Alves R, Mota S, Rodrigues CF, Silva S, Brown AJ, Henriques M, Casal M and Paiva S. (2017). The carboxylic acid transporters Jen1 and Jen2 affect Candida albicans biofilm architecture and fluconazole susceptibility in the presence of lactate. Biofouling 33(10): 943-954. I.F. 3.1

24. Ribas, D., Sá-Pessoa, J., Soares-Silva I., Nigard, Y., Paiva, S., Ryohonen, L., Pentillä, M., Casal, M. (2017). Yeast as a tool to express sugar acid transporters with biotechnological interest. FEMS Yeast research. 1;17(2). doi: 10.1093/femsyr/fox005.

23. Casal M, Queirós O, Talaia G, Ribas D, Paiva S. (2016). Carboxylic Acids Plasma Membrane Transporters in Saccharomyces cerevisiae. Adv Exp Med Biol. 892:229-51. doi: 10.1007/978-3-319-25304-6_9.

22. Mota S, Alves R, Carneiro C, Silva S, Brown AJ, Istel F, Kuchler K, Sampaio P, Casal M, Henriques M and Paiva S (2015). Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate. Front Microbiol 6:919. doi:10.3389/fmicb.2015.00919.

21. Soares-Silva I, Ribas D, Foskolou Z, Barata B, Bessa D, Queiros O, Paiva S, Casal (2015). The Debaryomyces hansenii carboxylate transporters Jen1 homologues are functional in Saccharomyces cerevisiae. FEMS Yeast Res 15. 

20. Mota, S, Vieira N, Barbosa S, Delaveau T, Torchet C, Lesaux A, Garcia M, Pereira A, Lemoine S, Coulpier F, Darzacq X, Benard L, Tanner K, Banroques J, Casal M, Devaux F and Paiva S. (2014). Role of the DHH1 gene in the regulation of monocarboxylic acids transporters expression in Saccharomyces cerevisiae. PLOS ONE 9(11):e111589.

19. Lopes C, Fonseca P, Matamá T, Gomes A, Louro C, Paiva S, Vaz F. (2014). Protective Ag:TiO₂ thin films for pressure sensors in orthopedic prosthesis: the importance of composition, structural and morphological features on the biological response to the coatings. J Mater Sci Mater Med 25(9):2069-81

18. Sá-Pessoa J, Paiva S, Ribas D, Silva IJ, Viegas SC, Arraiano CM, Casal M. (2013). SATP (YaaH), a succinate-acetate transporter protein in Escherichia coli. Biochem J. 454(3):585-95.

17. Paiva S, Strachotová D, Ku?erová H, Hlavá?ek O, Mota S, Casal M, Palková Z, Váchová L. (2013). The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies. Biochem J. 454(3):551-8. 

16. Teixeira S, Sá R, Grangeia A, Silva J, Oliveira C, Ferráz L, Alves A, Paiva S, Barros A and Sousa M. (2013). Immunohystochemical analysis of CFTR in normal and disrupted spermatogenesis Syst Biol Reprod Med. 59(1):53-9.

15. Pacheco A, Talaia G, Sá-Pessoa J, Bessa D, Gonçalves MJ, Moreira R, Paiva S, Casal M, Queirós O. (2012). Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2. FEMS Yeast Res. 12(3):375-81. 

14. Becuwe M, Vieira N, Lara D, Gomes-Rezende J, Soares-Cunha C, Casal M, Haguenauer-Tsapis R, Vincent O, Paiva S*, Léon S*. (2012). A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis. J Cell Biol. 196(2):247-59.  *These authors contributed equally to this work.

13. Vieira N, Pereira F, Casal M, Brown AJ, Paiva S and Johansson B. (2010). Plasmids for in vivo construction of integrative Candida albicans vectors in Saccharomyces cerevisiae. Yeast. 27(11):933-9.

12. Vieira N, Casal M, Johansson B, Maccallum DM, Brown AJ and Paiva S (2009). Functional specialization and differential regulation of short chain carboxylic acid transporters in the pathogen Candida albicans. 75(6):1337-54.

11. Paiva S, Vieira N, Nondier I, Haguenauer-Tsapis R, Casal M and Urban-Grimal D. (2009). Glucose-induced ubiquitylation and endocytosis of the yeast Jen1 transporter: role of k63-linked ubiquitin chains. J Biol Chem. 284: 19228-36.

10. Casal M, Paiva S, Queirós O. and Soares-Silva I. (2008). Transport of carboxylic acids in yeast. FEMS Microbiol Rev 32(6): 974-94.

9. Soares-Silva I, Paiva S, Diallinas G. and Casal M. (2007). The conserved sequence NXX[S/T]HX[S/T] QDXXXT of the Lactate/Pyruvate:H+ Symporter Subfamily, is critical for Jen1p kinetics and specificity. Mol Membr Biol 24: 464-474.

8. Queiros O, Pereira L, Paiva S, Moradas-Ferreira P. and Casal M. (2007). Functional analysis of Kluyveromyces lactis carboxylic acids permeases: heterologous expression of KlJEN1 and KlJEN2 genes. Curr Genet 51: 161-169.

7. Ramalho PA, Paiva S, Cavaco-Paulo A, Casal M, Cardoso MH and Ramalho MT. (2005). A key role of a plasma membrane redox system in the decolourization of azo dyes by the yeast Saccharomyces cerevisiae. Appl Environ Microbiol 71: 3882-8.

6. Soares-Silva I, Paiva S, Kotter P, Entian KD and Casal M. (2004). The disruption of JEN1 from Candida albicans impairs the transport of lactate. Mol Membr Biol 21: 403-411.

5. Paiva S, Devaux F, Barbosa S, Jacq C and Casal M. (2004). Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae. Yeast, 21: 201-210.

4. Paiva S, Kruckeberg A L and Casal M. (2002). Utilization of GFP as a marker for studying the expression and turnover of JEN1 of Saccharomyces cerevisiae. Biochem J., 363: 737-44.

3. Makuc J*, Paiva S*, Schauen M*, Krämer R, André B, Casal M, Leão C and Boles E. (2001). The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Yeast , 15: 1131-43. *These authors contributed equally to this work.

2. Casal M, Paiva S, Andrade R, Gancedo C e Leão C. (1999). The Lactate-Proton Symport of Saccharomyces cerevisiae is encoded by JEN1. J. Bacteriol. 181: 2620-2623.

1. Paiva S, Althoff S, Casal M e Leão C. (1999). Transport of acetate in mutants of Saccharomyces cerevisiae defective in monocarboxylate permeases. FEMS Microbiol. Lett. 170: 301-306.

26. Talaia G, Gournas C; Saliba E; Barata-Antunes C; Casal M; André B; Diallinas G; Paiva S. (2017). The ?-arrestin Bul1p mediates the endocytic turnover of Jen1p lactate transporter in response to alkalinization and distinct physiological signals. Journal of Molecular Biology. 429(23): 3678-3695.

25. Alves R, Mota S, Rodrigues CF, Silva S, Brown AJ, Henriques M, Casal M and Paiva S. (2017). The carboxylic acid transporters Jen1 and Jen2 affect Candida albicans biofilm architecture and fluconazole susceptibility in the presence of lactate. Biofouling 33(10): 943-954. I.F. 3.1

24. Ribas, D., Sá-Pessoa, J., Soares-Silva I., Nigard, Y., Paiva, S., Ryohonen, L., Pentillä, M., Casal, M. (2017). Yeast as a tool to express sugar acid transporters with biotechnological interest. FEMS Yeast research. 1;17(2). doi: 10.1093/femsyr/fox005.

23. Casal M, Queirós O, Talaia G, Ribas D, Paiva S. (2016). Carboxylic Acids Plasma Membrane Transporters in Saccharomyces cerevisiae. Adv Exp Med Biol. 892:229-51. doi: 10.1007/978-3-319-25304-6_9.

22. Mota S, Alves R, Carneiro C, Silva S, Brown AJ, Istel F, Kuchler K, Sampaio P, Casal M, Henriques M and Paiva S (2015). Candida glabrata susceptibility to antifungals and phagocytosis is modulated by acetate. Front Microbiol 6:919. doi:10.3389/fmicb.2015.00919.

21. Soares-Silva I, Ribas D, Foskolou Z, Barata B, Bessa D, Queiros O, Paiva S, Casal (2015). The Debaryomyces hansenii carboxylate transporters Jen1 homologues are functional in Saccharomyces cerevisiae. FEMS Yeast Res 15. 

20. Mota, S, Vieira N, Barbosa S, Delaveau T, Torchet C, Lesaux A, Garcia M, Pereira A, Lemoine S, Coulpier F, Darzacq X, Benard L, Tanner K, Banroques J, Casal M, Devaux F and Paiva S. (2014). Role of the DHH1 gene in the regulation of monocarboxylic acids transporters expression in Saccharomyces cerevisiae. PLOS ONE 9(11):e111589.

19. Lopes C, Fonseca P, Matamá T, Gomes A, Louro C, Paiva S, Vaz F. (2014). Protective Ag:TiO₂ thin films for pressure sensors in orthopedic prosthesis: the importance of composition, structural and morphological features on the biological response to the coatings. J Mater Sci Mater Med 25(9):2069-81

18. Sá-Pessoa J, Paiva S, Ribas D, Silva IJ, Viegas SC, Arraiano CM, Casal M. (2013). SATP (YaaH), a succinate-acetate transporter protein in Escherichia coli. Biochem J. 454(3):585-95.

17. Paiva S, Strachotová D, Ku?erová H, Hlavá?ek O, Mota S, Casal M, Palková Z, Váchová L. (2013). The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies. Biochem J. 454(3):551-8. 

16. Teixeira S, Sá R, Grangeia A, Silva J, Oliveira C, Ferráz L, Alves A, Paiva S, Barros A and Sousa M. (2013). Immunohystochemical analysis of CFTR in normal and disrupted spermatogenesis Syst Biol Reprod Med. 59(1):53-9.

15. Pacheco A, Talaia G, Sá-Pessoa J, Bessa D, Gonçalves MJ, Moreira R, Paiva S, Casal M, Queirós O. (2012). Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2. FEMS Yeast Res. 12(3):375-81. 

14. Becuwe M, Vieira N, Lara D, Gomes-Rezende J, Soares-Cunha C, Casal M, Haguenauer-Tsapis R, Vincent O, Paiva S*, Léon S*. (2012). A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis. J Cell Biol. 196(2):247-59.  *These authors contributed equally to this work.

13. Vieira N, Pereira F, Casal M, Brown AJ, Paiva S and Johansson B. (2010). Plasmids for in vivo construction of integrative Candida albicans vectors in Saccharomyces cerevisiae. Yeast. 27(11):933-9.

12. Vieira N, Casal M, Johansson B, Maccallum DM, Brown AJ and Paiva S (2009). Functional specialization and differential regulation of short chain carboxylic acid transporters in the pathogen Candida albicans. 75(6):1337-54.

11. Paiva S, Vieira N, Nondier I, Haguenauer-Tsapis R, Casal M and Urban-Grimal D. (2009). Glucose-induced ubiquitylation and endocytosis of the yeast Jen1 transporter: role of k63-linked ubiquitin chains. J Biol Chem. 284: 19228-36.

10. Casal M, Paiva S, Queirós O. and Soares-Silva I. (2008). Transport of carboxylic acids in yeast. FEMS Microbiol Rev 32(6): 974-94.

9. Soares-Silva I, Paiva S, Diallinas G. and Casal M. (2007). The conserved sequence NXX[S/T]HX[S/T] QDXXXT of the Lactate/Pyruvate:H+ Symporter Subfamily, is critical for Jen1p kinetics and specificity. Mol Membr Biol 24: 464-474.

8. Queiros O, Pereira L, Paiva S, Moradas-Ferreira P. and Casal M. (2007). Functional analysis of Kluyveromyces lactis carboxylic acids permeases: heterologous expression of KlJEN1 and KlJEN2 genes. Curr Genet 51: 161-169.

7. Ramalho PA, Paiva S, Cavaco-Paulo A, Casal M, Cardoso MH and Ramalho MT. (2005). A key role of a plasma membrane redox system in the decolourization of azo dyes by the yeast Saccharomyces cerevisiae. Appl Environ Microbiol 71: 3882-8.

6. Soares-Silva I, Paiva S, Kotter P, Entian KD and Casal M. (2004). The disruption of JEN1 from Candida albicans impairs the transport of lactate. Mol Membr Biol 21: 403-411.

5. Paiva S, Devaux F, Barbosa S, Jacq C and Casal M. (2004). Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae. Yeast, 21: 201-210.

4. Paiva S, Kruckeberg A L and Casal M. (2002). Utilization of GFP as a marker for studying the expression and turnover of JEN1 of Saccharomyces cerevisiae. Biochem J., 363: 737-44.

3. Makuc J*, Paiva S*, Schauen M*, Krämer R, André B, Casal M, Leão C and Boles E. (2001). The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. Yeast , 15: 1131-43. *These authors contributed equally to this work.

2. Casal M, Paiva S, Andrade R, Gancedo C e Leão C. (1999). The Lactate-Proton Symport of Saccharomyces cerevisiae is encoded by JEN1. J. Bacteriol. 181: 2620-2623.

1. Paiva S, Althoff S, Casal M e Leão C. (1999). Transport of acetate in mutants of Saccharomyces cerevisiae defective in monocarboxylate permeases. FEMS Microbiol. Lett. 170: 301-306.

9.Silva E, Casal M, Paiva S, Queirós O. (2012). Subcellular Localizations of the Monocarboxylate Transporters MCT1 Tagged with Green Fluorescence Protein in Different Cancer Cell Lines. Exp Clin Endocrinol Diabetes 2012; 120-A30. DOI: 10.1055/s-0032-1330825.

8. Léon S, Becuwe M, Vieira N, Lara D, Casal M, Vincent O, Paiva S and Haguenauer-Tsapis R. (2011). Connecting glucose signalling to ubiquitin-dependent transporter endocytosis: Arrestin the culprit!. 25th International Conference on yeast Genetics and Molecular Biology. Olsztyn, Poland. 11-16 July 2011. Yeast Vol 28, Supp 1.

7. Vieira N, Pereira F, Paiva S, Casal M, Brown A and Johansson B. Plasmids for in vivo construction of integrative Candida albicans vectors in Saccharomyces cerevisiae. 25th International Conference on Yeast Genetics and Molecular biology. Olsztyn, Poland. 11-16 July 2011. Yeast Vol 28, Supp 1.

6. Queirós O, Paiva S, Moradas-Ferreira P and Casal M. (2003). Molecular and physiological characterization of monocarboxylic acids permeases in the yeast Kluyveromyces lactis. Yeast, 20. Book of abstracts of the XXI International Conference on Yeast Genetics and Molecular Biology, Göteborg, Sweden.

5. Paiva S, Soares-Silva I, Kötter P, Entian KD and Casal M. (2003). The disruption of JEN1 from Candida albicans impairs the transport of lactate. Yeast, 20. Book of abstracts of the XXI International Conference on Yeast Genetics and Molecular Biology, Göteborg, Sweden.

4. Paiva S, Makuc J, Schauen M, Krämer R, André B, Casal M, Leão C and Boles E. (2001). The putative monocarboxylate permeases of the yeast Saccharomyces cerevisiae do not transport monocarboxylic acids across the plasma membrane. European Journal of Biochemestry 268/1, 53. Book of Abstracts of the 27th Meetting of the FEBS and Pan-American Association Molecular Biology. Lisbon, Portugal.

3. Paiva S, Kruckeberg A and Casal M. (2001). “Catabolite inactivation of the lactate transporter in Saccharomyces cerevisiae: ubiquitination, endocytosis and degradation in the vacuole”. Yeast, 18. Book of Abstracts YEAST 2001: XXth International Conference on Yeast Genetics and Molecular Biology. Prague, Check Republic, 2001.

2. Paiva S, Casal M and Leão C. (1999). Genetic characterization of monocarboxylic acids transporters of Saccharomyces cerevisiae. Folia Microbiol. 44 (2): 219-240. Book of Abstracts of the 16th Small Meeting on Yeast Transport and Energetics (SMYTE), Bratislava, Eslováquia.

1. Casal M, Paiva S, Andrade RP and Leão C. (1999). Genetic and functional analysis of the Saccharomyces cerevisiae gene JEN1 encoding the lactate permease. Current Genetics, 35 (nº 3-4). Book of Abstracts of the XIX International Conference on Yeast Genetics and Molecular Biology, Rimini, Italy.

Research Mentoring

Post-Doctoral Fellows

Isabel João Soares-Silva(February 2008-January 2009). Pos-Doc scholarship SFRH/BPD/22976/2005.

PhD Students

Neide Marina Vieira (January 2006-April 2010). Thesis entitled “Molecular Biology of Carboxylic Acids permeases in Yeasts: from physiology towards structure-function analysis” PhD scholarship SFRH/BD/23503/2005.

Gabriel Rocha (started October 2012). Thesis entitled “Endocytic trafficking and ubiquitylation of plasma membrane transporters in yeast”. PhD scholarship SFRH/BD/86221/2012.

Jéssica Angélica Rezende Gomes (started October 2011). PhD scholarship SFRH/BD/86759/2012.

Sandra Marlene da Silva Mota (started January 2010). Thesis entitled “Study of the mechanisms of transport and regulation of carboxylic acids in Candida albicans and Candida glabrata”. PhD scholarship SFRH/BD/66729/2009.

Joana Margarida Sá Pessoa da Graça Santos (started September 2009). Thesis entitled "Structural functional studies of plasma membrane carboxylate transporters in yeasts” PhD scholarship SFRH/BD/61530/2009.

Master Students Master thesis in Molecular Genetics of Elsa Silva. Thesis entitled “Intracellular Trafficking of Plasma Membrane Transporters in Mammalian Cells”. University of Minho (ongoing).

Master thesis in Science Communication of Ana Isabel Pinheiro. Thesis entitled “Development and implementation of different science communication and science outreach strategies – a project for the school of sciences of University of Minho”. University of Lisbon (ongoing).

Master thesis in Molecular Genetics of Gabriel Rocha, with the work entitled "Characterization of monocarboxylate membrane transporters in Saccharomyces cerevisiae". October 2011-December 2012, University of Minho.

Master thesis in Molecular Genetics of Jéssica Angélica Rezende Gomes, with the work entitled "Regulation and characterization of carboxylic acid transporters in Saccharomyces cerevisiae and Candida glabrata". October 2009-January 2011, University of Minho.

Master thesis in Molecular Genetics of Daniela Silva, with the work entitled "Physiological and Molecular studies of carboxylate transporter homologues in Yarrowia lipolytica". October 2009 - January 2011, University of Minho.

Master thesis in Molecular Physiology of Plants of Henrique Luis Silva de Noronha, with the work entitled "The effect of high temperature on sugar transport in grape cells". September 2008-September 2009. University of Minho.

Other Supervisions Supervisor of Gabriela Filipa Lopes Ribeiro and Neide Vieira as a BI grant holders of the project PermYeast.